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Prader Willi Syndrome (PWS)

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Prader-Willi syndrome is a rare complex genetic disorder caused by the loss of function of genes on chromosome 15q11-q13, typically resulting from a deletion on the paternal copy of that chromosome or from inheriting two maternal copies instead of one from each parent. It is one of the most common genetic causes of life-threatening obesity. The syndrome directly affects the hypothalamus, the region of the brain responsible for hunger, satiety, growth hormone production, body temperature regulation, sleep, and mood. Core features include low muscle tone at birth, intellectual disability, behavioral challenges, insatiable appetite beginning in early childhood, and significantly elevated risk of obesity and its associated complications. Hormonal deficiencies affecting growth, thyroid function, and metabolism are also characteristic, and many individuals require lifelong supervision and support.

Close-up of a neuron with a fiery orange glow on a dark background

The hypothalamus is the body's thermostat, and PWS damages it
The hypothalamus governs the body's core temperature regulation. Because PWS is fundamentally a hypothalamic disorder, individuals with PWS present with abnormalities in thermoregulation, an impaired ability to detect temperature change, and altered perception of pain, all indicating dysfunction of the autonomic nervous system. Source: MDPI

Like Phelan-McDermid syndrome, PWS involves reduced perception of pain and temperature change, meaning individuals, particularly those with intellectual disability or limited communication, may not recognize or express that they are overheating. Caregivers must monitor and intervene proactively, making accessible, wearable cooling tools especially practical for this population.

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Please consult a licensed healthcare practitioner before using any hot/cold therapy or body cooling product for a medical condition.

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